Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects

S Mackey; N Allgaier; B Chaarani; P Spechler; C Orr; J Bunn; NB Allen; N Alia-Klein; A Batalla; S Blaine; S Brooks; E Caparelli; YY Chye; J Cousijn; A Dagher; S Desrivieres; S Feldstein-Ewing; JJ Foxe; RZ Goldstein; AE Goudriaan; MM Heitzeg; R Hester; K Hutchison; O Korucuoglu; CSR Li; E London; V Lorenzetti; M Luijten; R Martin-Santos; A May; R Momenan; A Morales; MP Paulus; G Pearlson; ME Rousseau; BJ Salmeron; R Schluter; L Schmaal; G Schumann; Z Sjoerds; DJ Stein; EA Stein; R Sinha; N Solowij; S Tapert; A Uhlmann; D Veltman; R Van Holst; S Whittle; MJ Wright; M Yücel; S Zhang; D Yurgelun-Todd; DP Hibar; N Jahanshad; A Evans; PM Thompson; DC Glahn; P Conrod; H Garavan

Journal article

Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects

S Mackey, N Allgaier, B Chaarani, P Spechler, C Orr, J Bunn, NB Allen, N Alia-Klein, A Batalla, S Blaine, S Brooks, E Caparelli, YY Chye, J Cousijn, A Dagher, S Desrivieres, S Feldstein-Ewing, JJ Foxe, RZ Goldstein, AE Goudriaan Show all

American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2019

DOI: 10.1176/appi.ajp.2018.17040415

Abstract

Objective: Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes. Method..

View full abstract

University of Melbourne Researchers

Nick Allen Author

Rob Hester Author

Lianne Schmaal Author

Sarah Whittle Author

Related Projects (1)

A GLOBAL ALLIANCE TO UNLOCK BRAIN MECHANISMS INFLUENCING SUICIDAL BEHAVIORS THROUGH THE ENIGMA CONSORTIUM

ABSTRACT One million people around the world die from suicide annually. Suicide is the tenth leading cause of death for all ages and the sec..

Grants

Awarded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Funding Acknowledgements

Supported by NIDA grant 1R21DA038381 to Dr. Garavan and by NIH grant U54 EB 020403 with funds provided for the trans-NIH Big Data to Knowledge (BD2K) initiative. Data collection: Dr. Korucuoglu received support for the Neuro-ADAPT study from VICI grant 453.08.01 from the Netherlands Organization for Scientific Research (NWO), awarded to Reinout W. Wiers. Drs. Schmaal and Veltman received funding from Netherlands Organization for Health Research and Development (ZonMW) grant 31160003 from NWO. Drs. Sjoerds and Veltman received funding from ZonMW grant 31160004 from NWO. Drs. Goudriaan and van Holst received funding from ZonMW grant 91676084 from NWO. Drs. Luijten and Veltman received funding from VIDI grant 016.08.322 from NWO, awarded to Ingmar H.A. Franken. Drs. Cousijn and Goudriaan received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. Drs. Garavan and Foxe received funds from NIDA grant R01-DA014100. Dr. Li received funding from NIDA grants R01AA021449, R01DA023248, and K25DA040032. Dr. London was supported by NIDA grant R01 DA020726, the Thomas P. and Katherine K. Pike Chair in Addiction Studies, the Endowment From the Marjorie Greene Family Trust, and UCLA contract 20063287 with Philip Morris USA. Data collection by Dr. Momenan was supported by the Intramural Clinical and Biological Research Program of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Morales was supported by NIDA grant T32 DA024635. Dr. Paulus received funding from NIMH grant R01 DA018307. Dr. Stein was supported by the Intramural Research Program of NIDA and NIH. Dr. Sinha received funds from NIDA (PL30-1DA024859-01), the NIH National Center for Research Resources (UL1-RR24925-01), and NIAAA (R01-AA013892). Dr. Solowij received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. Prof. Yucel was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund.